Description

3-Methylbutyryl-D9 Chloride is a deuterated isotopologue of isovaleryl chloride, where nine hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This high isotopic purity makes it an essential internal standard and precursor in quantitative mass spectrometry and metabolic studies, ensuring unparalleled analytical accuracy. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced material scientists working on tracer studies, pharmacokinetics, and the synthesis of labeled compounds.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of isovaleryl-CoA and related metabolites in complex biological matrices.
• Deuterated Pharmaceutical Intermediate: Used in the synthesis of deuterium-labeled drug candidates to study metabolic pathways and improve drug stability.
• Metabolic Tracer Studies: Enables detailed investigation of fatty acid and branched-chain amino acid metabolism in research.
• Stable Isotope Labeling: Serves as a key building block for preparing labeled standards and reagents used in proteomics and metabolomics.
• Organic Synthesis Research: Acts as a specialized acylating agent for introducing the deuterated 3-methylbutyryl moiety in synthetic chemistry.

Basic Information

Product Name	3-Methylbutyryl-D9 Chloride
CAS No.	1219803-46-9
Molecular Formula	C5D9ClO
Molecular Weight	128.62 g/mol (for D9 isotopologue)
Synonyms	Isovaleryl-D9 Chloride; 3-Methylbutanoyl-D9 Chloride; Deuterated Isovaleryl Chloride (D9); (3-Methylbutyryl)-D9 Chloride; Isobutylacetyl-D9 Chloride; 3-Methylbutyroyl-D9 Chloride; Isopentanoyl-D9 Chloride; 1219803-46-9
EINECS	Contact for details

Quality Control

Our 3-Methylbutyryl-D9 Chloride is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % D), chemical purity by NMR and GC/HPLC, and identity confirmation. We adhere to cGMP principles for pharmaceutical-grade materials, ensuring traceability and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures between 2°C and 8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition upon contact with atmospheric moisture.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR/NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % D)	≥ 99.0% (by MS or NMR)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.