Description

3,4-Dimethoxyphenylacetonitrile-A,A-D2 is a high-purity, deuterium-labeled organic compound, specifically designed for advanced research and development. This isotopically labeled analog is a critical building block in the synthesis of complex molecules, offering enhanced metabolic stability and traceability in analytical studies. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and academic researchers in the fields of medicinal chemistry, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the development of new Active Pharmaceutical Ingredients (APIs), particularly in neurological and cardiovascular research.
• Metabolic & Pharmacokinetic Studies: Used as an internal standard or tracer in mass spectrometry (LC-MS, GC-MS) for accurate quantification and drug metabolism studies (DMPK).
• Process Chemistry & Impurity Profiling: Essential for investigating reaction mechanisms and identifying/degradant pathways during API scale-up and manufacturing.
• Agrochemical Research: Serves as a precursor in the synthesis of novel, labeled agrochemicals for environmental fate and residue analysis.
• Material Science: Potential building block for advanced organic electronic materials and liquid crystals.

Basic Information

Product Name	3,4-Dimethoxyphenylacetonitrile-A,A-D2
CAS No.	1219803-34-5
Molecular Formula	C₁₀H₉D₂NO₂
Molecular Weight	179.22 g/mol
Synonyms	3,4-Dimethoxybenzeneacetonitrile-α,α-d2; (3,4-Dimethoxyphenyl)acetonitrile-d2; 3,4-Dimethoxybenzyl cyanide-d2; 3,4-Dimethoxyphenylacetonitrile-d2; Deuterated Veratrylacetonitrile; α,α-Dideutero-3,4-dimethoxyphenylacetonitrile; 2-(3,4-Dimethoxyphenyl)acetonitrile-α,α-d2
EINECS	Contact for details

Quality Control

Every batch of 3,4-Dimethoxyphenylacetonitrile-A,A-D2 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity (D-content), chemical purity (by HPLC/GC), and identity confirmation (by NMR, IR). Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.