Description

Piperidine-D10-Carbonyl Chloride is a deuterated derivative of piperidine carbonyl chloride, where ten hydrogen atoms are replaced with deuterium, serving as a crucial stable isotope-labeled building block. This high-purity compound is essential for creating internal standards and labeled analogs for precise quantitative analysis in advanced research. It is primarily utilized by pharmaceutical, agrochemical, and analytical chemistry laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and environmental trace analysis.

Application

• Internal Standard for LC-MS/MS: Used as a critical internal standard in Liquid Chromatography-Mass Spectrometry for the accurate quantification of piperidine-containing drugs and metabolites.
• Deuterated Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) for clinical research.
• Metabolite Tracing & Proteomics: Enables precise tracking of metabolic pathways and protein labeling in mechanistic biological studies.
• Environmental Analysis: Employed in the development of analytical methods for detecting piperidine-based compounds in complex environmental matrices.
• Agrochemical Research: Used in the synthesis of labeled agrochemicals to study their environmental fate, degradation, and residue analysis.
• NMR Spectroscopy: Acts as a valuable reagent for NMR spectroscopic studies due to its distinct deuterium signature, reducing signal interference.

Basic Information

Product Name	Piperidine-D10-Carbonyl Chloride
CAS No.	1219803-31-2
Molecular Formula	C6D10ClNO
Molecular Weight	155.66 g/mol (for deuterated form)
Synonyms	Perdeuterated Piperidine Carbonyl Chloride; Piperidine-2,2,3,3,4,4,5,5,6,6-D10-carbonyl Chloride; Piperidine-d10 Carbonyl Chloride; Piperidine-1-carbonyl chloride-d10; Deuterated Piperidine-1-Carbonyl Chloride; Hexadeutero-piperidine-1-carbonyl chloride; (Perdeuteropiperidin-1-yl)methanone chloride
EINECS	Contact for details

Quality Control

Our Piperidine-D10-Carbonyl Chloride is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity by NMR and HPLC, and impurity profiles. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.