Description

2-Bromo-4'-Fluoroacetophenone--D4 is a high-purity, deuterium-labeled derivative of 2-bromo-4'-fluoroacetophenone, a key intermediate in advanced organic synthesis. This compound is specifically valued for its role in mass spectrometry and analytical chemistry, where its isotopic labeling provides critical internal standards for precise quantification and metabolic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, development, and regulatory analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of its non-deuterated counterpart and related metabolites in complex biological matrices.
• Pharmaceutical Research: Used as a stable isotope-labeled intermediate in the synthesis and pharmacokinetic (PK) studies of novel drug candidates.
• Metabolite Identification: Aids in the identification and structural elucidation of drug metabolites using mass spectrometric techniques.
• Organic Synthesis Building Block: Functions as a specialized synthon for introducing deuterium labels into more complex molecular architectures for research purposes.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific bioanalytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	2-Bromo-4'-Fluoroacetophenone--D4
CAS No.	1219803-30-1
Molecular Formula	C8H4D4BrFO
Molecular Weight	219.07 g/mol (approx.)
Synonyms	1-(4-Fluorophenyl)-2-bromoethanone-d4; 2-Bromo-1-(4-fluorophenyl)ethanone-d4; 4'-Fluoro-2-bromoacetophenone-d4; p-Fluoro-α-bromoacetophenone-d4; α-Bromo-4'-fluoroacetophenone-d4; Deuterated 2-Bromo-4'-fluoroacetophenone; [D4]-2-Bromo-4'-fluoroacetophenone; 2-Bromo-4'-fluoroacetophenone (phenyl-d4)
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4'-Fluoroacetophenone--D4 is produced and analyzed under strict quality management protocols to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.