Description

4-Piperidine-D9-Carboxamide is a high-purity, deuterium-labeled isotopologue of piperidine-4-carboxamide, serving as a critical stable isotope-labeled internal standard and building block. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies, where precise measurement is paramount. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and forensic analysis.

Application

• Quantitative Mass Spectrometry: Used as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of piperidine-4-carboxamide and related analogs in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates, improving data precision.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific LC-MS/MS methods for preclinical and clinical studies.
• Forensic & Clinical Toxicology: Supports the detection and quantification of specific substances or their metabolites in forensic and clinical toxicology screenings.
• Metabolomics Research: Acts as a reference compound in targeted metabolomics to study biochemical pathways and disease biomarkers.
• Synthetic Chemistry: Serves as a deuterated building block for the synthesis of more complex labeled compounds for research purposes.

Basic Information

Product Name	4-Piperidine-D9-Carboxamide
CAS No.	1219803-20-9
Molecular Formula	C6D9H2N2O
Molecular Weight	131.21 g/mol (for D9 isotopologue)
Synonyms	Piperidine-4-carboxamide-d9; 4-Carbamoylpiperidine-d9; Isonipecotamide-d9; 4-Piperidinecarboxamide-d9; NSC 401005-d9; Perdeuterated 4-Piperidinecarboxamide; (D9)-4-Piperidinecarboxamide; 4-Aminocarbonylpiperidine-d9
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced and controlled under stringent quality management systems to ensure exceptional isotopic purity and chemical integrity, which are critical for analytical applications. Each batch of 4-Piperidine-D9-Carboxamide is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.