Description

Glyburide-D3 is a deuterium-labeled analog of the widely used second-generation sulfonylurea antidiabetic agent, Glyburide (Glibenclamide). This high-purity stable isotope-labeled compound is essential for advanced pharmaceutical research and development, particularly in drug metabolism and pharmacokinetic (DMPK) studies. It serves as a critical internal standard in quantitative bioanalytical methods using LC-MS/MS, ensuring accurate and reliable data. Researchers and analytical laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors require this material for developing robust assays and conducting precise metabolic profiling.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative internal standard in the bioanalysis of Glyburide in biological matrices (plasma, serum, urine) to enhance accuracy and precision.
• Drug Metabolism Studies (DMPK): Employed in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Glyburide.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Facilitates precise measurement of drug concentration-time profiles in preclinical and clinical research.
• Method Development and Validation: Critical for developing and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Stable Isotope Dilution Assays: Utilized in isotope dilution techniques for the absolute quantification of Glyburide in complex samples.
• Reference Material: Acts as a certified reference material (CRM) or high-grade chemical reference standard in quality control laboratories.

Basic Information

Product Name	Glyburide-D3
CAS No.	1219803-02-7
Molecular Formula	C23H25D3ClN3O5S
Molecular Weight	498.02 g/mol (for deuterated form)
Synonyms	Glibenclamide-D3; 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide-D3; 1-[[p-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea-D3; Glybenzcyclamide-D3; HB 419-D3; DAONIL-D3; EUGLUCON-D3; Micronase-D3
EINECS	Contact for details

Quality Control

Our Glyburide-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for critical parameters including chemical purity (HPLC), isotopic enrichment (NMR/MS), and identity confirmation (IR, MS). We adhere to industry best practices, and our quality system supports the needs of research requiring reliable and consistent reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.