Description

Carboxytolbutamide-D9 (Butyl-D9) is a high-purity, deuterium-labeled internal standard used in quantitative analytical chemistry. This compound is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers for the precise measurement of tolbutamide and its metabolites.

Application

• Internal standard for the LC-MS/MS quantification of tolbutamide in biological matrices (plasma, serum, urine).
• Metabolite profiling and drug metabolism and pharmacokinetics (DMPK) studies in pharmaceutical R&D.
• Use in clinical research and bioanalytical method development and validation.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing definitive analytical data.
• Application in isotope dilution mass spectrometry for high-accuracy measurements.
• Quality control and assurance in the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Carboxytolbutamide-D9 (Butyl-D9)
CAS No.	1219802-95-5
Molecular Formula	C12H9D9N2O3S
Molecular Weight	279.37 g/mol (for deuterated form)
Synonyms	1-Butyl-3-(p-carboxyphenyl)sulfonylurea-D9; 4-[[[(Butyl-D9)amino]carbonyl]amino]sulfonyl]benzoic Acid; Tolbutamide Carboxylic Acid-D9; Tolbutamide Metabolite Standard-D9; Deuterated Tolbutamide Carboxylic Acid; Isotopically Labeled Internal Standard; p-Carboxytolbutamide-D9
EINECS	Contact for details

Quality Control

Our Carboxytolbutamide-D9 is manufactured under strict quality systems to ensure exceptional purity and isotopic enrichment. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and mass spectrometry. We ensure compliance with relevant standards for high-purity reference materials, supporting GMP and GLP environments where traceability and data integrity are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.