Description

o-Tolyl-D7 Isocyanate is a deuterium-labeled derivative of o-tolyl isocyanate, where seven hydrogen atoms are replaced with deuterium, serving as a critical internal standard and tracer in advanced analytical chemistry. This isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies, eliminating interference from endogenous compounds. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, agrochemical, and material science sectors for method development, pharmacokinetic research, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the precise quantification of o-tolyl isocyanate and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Employed in pharmaceutical and agrochemical research to elucidate metabolic pathways and degradation products using deuterium as a non-radioactive tracer.
• Method Development and Validation: Critical for developing and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH Q2).
• Impurity Profiling and Reference Standard: Acts as a high-purity reference standard for identifying and quantifying impurities in active pharmaceutical ingredients (APIs) and chemical intermediates.
• Polymer Science Research: Used in studies involving polyurethane and polymer chemistry to track the incorporation and behavior of specific monomers.
• Environmental Fate Studies: Applied in environmental science to study the fate, transport, and breakdown of isocyanate compounds.

Basic Information

Product Name	o-Tolyl-D7 Isocyanate
CAS No.	1219802-73-9
Molecular Formula	C8D7NO
Molecular Weight	138.19 g/mol
Synonyms	2-Methylphenyl-D7 isocyanate; (2-Methylphenyl-D7)isocyanate; o-Tolyl isocyanate-D7; 2-Isocyanato-1-methyl-D7-benzene; Deutero-o-tolyl isocyanate; Isotopic Labeled o-Tolyl Isocyanate; D7-o-TIC; CAS 1219802-73-9
EINECS	Contact for details

Quality Control

Every batch of o-Tolyl-D7 Isocyanate is manufactured and analyzed under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuterium incorporation and chemical identity, ensuring compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures (typically 2-8°C or as specified on the label). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.