Description

Iodoacetamide-D4 is a deuterium-labeled analog of iodoacetamide, a critical alkylating agent used to modify cysteine residues in proteins and peptides. This stable isotope-labeled compound is essential for quantitative proteomics and mass spectrometry-based research, providing an internal standard for accurate measurement and reducing signal variability. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and biochemistry for applications requiring precise quantification and metabolic pathway tracing.

Application

• Quantitative Proteomics: Serves as a crucial internal standard in mass spectrometry for the absolute quantification of proteins and peptides.
• Biomarker Discovery: Used in isotope-coded affinity tag (ICAT) and related techniques to compare protein expression levels between different biological samples.
• Metabolic Studies: Enables tracing and quantification of biochemical pathways in deuterium-labeling experiments.
• Protein Chemistry Research: Acts as a cysteine-specific alkylating agent for studying protein structure, function, and disulfide bond mapping.
• Pharmaceutical R&D: Employed in the development and validation of bioanalytical methods for drug candidates and biomarkers.
• Quality Control Standards: Used to prepare certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	Iodoacetamide-D4
CAS No.	1219802-64-8
Molecular Formula	C2D4INO
Molecular Weight	186.98 g/mol
Synonyms	2-Iodoacetamide-d4; Deuterated Iodoacetamide; Iodoacetamide-2,2,2',2'-d4; IAA-d4; N-(Carbamoylmethyl)-2-iodoacetamide-d4; Acetamide, 2-iodo-N-(2H3)methyl-2,2-d2-; (2H4)-2-Iodoacetamide
EINECS	Contact for details

Quality Control

Our Iodoacetamide-D4 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles to ensure it meets the exacting standards required for advanced research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.