Description

n-Acetyl-D3-Glycine-D2-n-Methyl-D3-Amide is a high-purity, multi-deuterated isotopologue of N-acetylglycine N-methylamide, specifically designed for advanced research and development. This compound matters as a critical stable isotope-labeled internal standard and tracer, enabling precise quantification and metabolic pathway elucidation in complex biological matrices. It is essential for researchers and analytical scientists in pharmaceutical development, clinical research, and metabolomics who require uncompromising isotopic purity and chemical stability for sensitive mass spectrometry (MS) and nuclear magnetic resonance (NMR) applications.

Application

• Internal Standard for LC-MS/MS & GC-MS: Provides accurate quantification of N-acetylglycine N-methylamide and related metabolites in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Tracer: Used in stable isotope-resolved metabolomics (SIRM) to track glycine and one-carbon metabolism in cell cultures, tissues, and animal models.
• Drug Metabolism & Disposition (DMPK): Facilitates the study of drug metabolism, enabling the identification and quantification of drug-derived metabolites.
• Biomarker Discovery & Validation: Serves as a reference compound in the development of clinical assays for disease-specific metabolic biomarkers.
• NMR Spectroscopy: Acts as a chemical shift reference or a probe for studying molecular structure and dynamics without signal interference from protons.
• Synthesis of Labeled Compounds: Used as a deuterated building block for the synthesis of more complex isotopically labeled molecules for research.

Basic Information

Product Name	n-Acetyl-D3-Glycine-D2-n-Methyl-D3-Amide
CAS No.	1219802-57-9
Molecular Formula	C5D8H2N2O2
Molecular Weight	136.18 g/mol (deuterated form)
Synonyms	N-Acetyl-D3-glycine-D2-N-methyl-D3-amide; N-Acetylglycine N-Methylamide-d8; Ac-Gly-NHMe-d8; (2,2-Dideutero-acetylamino)-N-(trideuteromethyl)acetamide; N-(Acetyl-d3)glycine-d2 N-methyl-d3 amide; Deuterated N-Acetylglycine N-Methylamide; Perdeuterated N-Acetylglycine Methylamide; Stable Isotope Labeled N-Acetylglycine Methylamide
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-D3-Glycine-D2-n-Methyl-D3-Amide is produced and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Our standard quality commitment includes comprehensive testing for isotopic enrichment (D, %), chemical purity, and identity confirmation. Certificates of Analysis (COA) detailing lot-specific results from NMR, HPLC, and MS are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 97%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.