Description

Methyl 2-Hydroxybenzoate--D4 is a deuterated isotopologue of methyl salicylate, where four hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and chemical manufacturers engaged in method development, pharmacokinetic studies, and metabolic pathway research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of methyl salicylate and related compounds in complex biological and environmental matrices.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of active pharmaceutical ingredients.
• Analytical Method Development: Serves as a stable, non-interfering reference standard for validating and calibrating sensitive analytical instruments.
• Metabolomics and Biomarker Discovery: Enables accurate profiling of metabolites in systems biology and clinical research applications.
• Forensic and Toxicology Testing: Provides definitive reference material for the accurate identification and quantification of substances in forensic analysis.
• Chemical Synthesis Research: Acts as a labeled starting material or intermediate in the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Product Name	Methyl 2-Hydroxybenzoate--D4
CAS No.	1219802-12-6
Molecular Formula	C8H4D4O3
Molecular Weight	156.17 g/mol
Synonyms	Methyl Salicylate-d4; 2-(Methoxy-d3-carbonyl)phenol-d; Deuterated Methyl Salicylate; Methyl 2-Hydroxybenzoate-d4; Salicylic Acid Methyl Ester-d4; Benzoic Acid, 2-Hydroxy-, Methyl Ester-d4; Wintergreen Oil-d4 (labeled analog); 2-Hydroxybenzoic Acid Methyl Ester-d4
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Hydroxybenzoate--D4 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous testing, including NMR, HPLC, and MS, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, assay, and impurity profiles is provided with each shipment to support your compliance and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; ensure the container is kept sealed in a dry environment to maintain stability and isotopic purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.