Description

1-Boc-4-(2-Hydroxyethyl-D4)Piperazine is a high-purity, deuterium-labeled building block of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable, isotopically labeled intermediate, enabling precise metabolic and pharmacokinetic studies. This compound is primarily needed by researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing novel active pharmaceutical ingredients (APIs) and conducting drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of deuterated drug candidates, enhancing metabolic stability and enabling patent life-cycle management.
• Metabolic Tracer: Used in mass spectrometry-based studies to track the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities.
• Internal Standard: Serves as a quantitative internal standard in bioanalytical assays (LC-MS/MS) for accurate measurement of non-labeled analogs in biological matrices.
• Proteomics & Biochemistry Research: Employed in the synthesis of isotopically labeled probes and ligands for studying protein-ligand interactions and signaling pathways.
• Chemical Biology Tool: Facilitates the creation of labeled molecules for mechanistic studies and pathway elucidation in complex biological systems.

Basic Information

Product Name	1-Boc-4-(2-Hydroxyethyl-D4)Piperazine
CAS No.	1219802-10-4
Molecular Formula	C11H17D4N2O3
Molecular Weight	233.31 g/mol
Synonyms	1-Boc-4-(2-Hydroxyethyl-d4)piperazine; tert-Butyl 4-(2-hydroxyethyl-d4)piperazine-1-carboxylate; 4-(2-Hydroxyethyl-d4)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl-d4)piperazine; Deuterated Boc-hydroxyethylpiperazine; Boc-Piperazine-d4-Ethanol; 1-Boc-4-(2-Hydroxyethyl-1,1,2,2-d4)piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2-Hydroxyethyl-D4)Piperazine is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for research integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC/NMR), isotopic enrichment (by MS), and identity confirmation. We adhere to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.