Description

Isonicotinamide--D4 is a high-purity, deuterium-labeled analog of isonicotinamide, a key intermediate in pharmaceutical and biochemical research. This stable isotope-labeled compound is essential for creating internal standards for mass spectrometry, enabling precise quantitative analysis and metabolic studies. It is primarily utilized by research institutions, pharmaceutical developers, and CROs (Contract Research Organizations) engaged in drug discovery, pharmacokinetics, and analytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of isonicotinamide and related compounds in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Analytical Method Development: Enables the validation and calibration of highly sensitive HPLC and mass spectrometry methods in quality control and research laboratories.
• Biochemical Research: Acts as a tool in enzymatic and receptor-binding studies where non-interfering isotopic labels are required.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Item	Detail
Product Name	Isonicotinamide--D4
CAS No.	1219799-40-2
Molecular Formula	C6H3D4N2O
Molecular Weight	125.15 g/mol
Synonyms	Isonicotinamide-d4; 4-Pyridinecarboxamide-d4; Deuteronated Isonicotinamide; Pyridine-4-carboxamide-d4; Iso-nicotinamide-d4; Isonicotinic acid amide-d4; 4-Carbamoylpyridine-d4; [2H4]-Isonicotinamide
EINECS	Contact for details

Quality Control

Our Isonicotinamide--D4 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including NMR, HPLC, and Mass Spectrometry reports. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.