Description

4-Hydroxypiperidine--D9 is a deuterium-labeled analog of 4-hydroxypiperidine, a versatile heterocyclic building block. This isotopically labeled compound is essential for advanced research and development, particularly in the fields of pharmaceutical and agrochemical discovery. It serves as a critical internal standard and tracer in mass spectrometry-based analytical methods, enabling precise quantification and metabolic pathway studies. Researchers in medicinal chemistry, analytical laboratories, and life sciences rely on this high-purity labeled compound for its reliability and consistency in sensitive applications.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical method development and validation for pharmacokinetic and metabolomic studies.
• Metabolic Pathway Tracing: Employed in drug metabolism and disposition (DMPK) research to track the fate of piperidine-containing drug candidates.
• Pharmaceutical Intermediate: Serves as a deuterated synthon in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for clinical trials.
• Analytical Reference Material: Provides a critical standard for ensuring accuracy and precision in high-performance liquid chromatography (HPLC) and mass spectrometry analyses.
• Mechanistic Studies: Facilitates research into reaction mechanisms and biological processes where non-labeled compounds would not provide sufficient differentiation.

Basic Information

Product Name	4-Hydroxypiperidine--D9
CAS No.	1219799-39-9
Molecular Formula	C5H2D9NO
Molecular Weight	115.22 g/mol
Synonyms	4-Hydroxypiperidine-d9; Piperidin-4-ol-d9; 1,2,2,3,3,4,5,5,6-Nonadeuterioperhydro-4-pyridinol; 4-Hydroxy-1-piperidine-d9; Deuterated 4-Hydroxypiperidine; 4-Piperidinol-d9; 4-HP-d9; 4-OH-Pip-d9
EINECS	Contact for details

Quality Control

Our 4-Hydroxypiperidine--D9 is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, meeting the stringent requirements of research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity (by HPLC/NMR), and residual solvent content. We adhere to cGMP principles for the production of reference standards, ensuring traceability, consistency, and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.