Description

Iodoacetic Acid-D3 is a deuterated isotopologue of iodoacetic acid, where three hydrogen atoms are replaced by deuterium. This compound is a crucial biochemical tool, primarily valued for its use as an internal standard in mass spectrometry-based proteomics and metabolomics, enabling precise quantification and reducing analytical variability. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors who require high-fidelity analytical standards for studying protein alkylation, metabolic pathways, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of iodoacetic acid and related compounds in complex biological matrices.
• Proteomics Research: Used in bottom-up proteomics for cysteine alkylation in protein sample preparation, with the deuterated form allowing for method development and standardization.
• Metabolomics Studies: Employed in metabolic flux analysis and the study of thiol-reactive metabolites within cellular systems.
• Biochemical Tracing: Acts as a tracer in mechanistic studies of enzyme inhibition, particularly for glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
• Pharmaceutical Analysis: Supports analytical method development and validation in drug metabolism and pharmacokinetics (DMPK) studies.
• Reference Material: Functions as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.

Basic Information

Product Name	Iodoacetic Acid-D3
CAS No.	1219799-36-6
Molecular Formula	C₂D₃IO₂
Molecular Weight	187.96 g/mol
Synonyms	Deuterated Iodoacetic Acid; Iodoacetic-d3 Acid; (D3)Iodoacetic Acid; 2-Iodoacetic-d3 Acid; Monoiodoacetic Acid-D3; IAA-d3; Deuterium Labeled Iodoacetate; Carboxymethyl-d3 Iodide
EINECS	Contact for details

Quality Control

Every batch of Iodoacetic Acid-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR, HPLC, and mass spectrometry to confirm identity, assay, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment ensures the material is suitable for sensitive analytical applications, including use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.