Description

3-(n-Morpholino)Propanesulfonic Acid-D15 is a deuterated analog of the widely used biological buffer MOPS, where fifteen hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications requiring high-resolution nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) as an internal standard or tracer. It is an essential tool for researchers and quality control laboratories in pharmaceutical development, metabolic studies, and analytical chemistry, providing unmatched precision for structural elucidation and quantitative analysis.

Application

• NMR Spectroscopy Internal Standard: Used as a chemical shift reference and quantitative internal standard in deuterated solvents for high-field NMR analysis.
• Mass Spectrometry Tracer: Serves as a stable isotope-labeled internal standard for accurate quantification in LC-MS and GC-MS methods, improving data reliability.
• Metabolic Pathway Research: Employed in tracing studies to investigate biochemical pathways and drug metabolism without interfering with natural biological processes.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Protein & Biomolecular NMR: Provides a stable pH environment in deuterated buffer systems for studying protein structure and dynamics.
• Quality Control & Method Development: Essential for developing and validating robust analytical methods in GMP/GLP-compliant laboratories.

Basic Information

Product Name	3-(n-Morpholino)Propanesulfonic Acid-D15
CAS No.	1219799-30-0
Molecular Formula	C7D15NO4S
Molecular Weight	229.33 g/mol (deuterated form)
Synonyms	MOPS-d15; 4-Morpholinepropanesulfonic Acid-d15; 3-(N-Morpholino)propanesulfonic Acid-d15; Deuterated MOPS; Perdeuterated MOPS; MOPS (D15); 3-(4-Morpholinyl)-1-propanesulfonic Acid-d15; 3-Morpholinopropanesulfonic Acid-d15
EINECS	Contact for details

Quality Control

Our 3-(n-Morpholino)Propanesulfonic Acid-D15 is manufactured under controlled conditions to ensure exceptional isotopic purity and chemical integrity. Each batch undergoes rigorous analysis, including NMR for deuterium incorporation and HPLC for chemical purity, to meet the stringent requirements of analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect isotopic purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Deuterium Enrichment (NMR)	≥ 98 atom % D
Assay (HPLC)	≥ 98.0%
pH (1% Solution)	6.5 - 7.5
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.