Description

n-Butyrylglycine-2,2-D2 is a stable isotope-labeled analog of the endogenous metabolite n-butyrylglycine, specifically deuterated at the 2,2 positions of the glycine moiety. This compound is of critical importance for use as an internal standard in quantitative mass spectrometry-based analyses, ensuring high accuracy and reproducibility in metabolic profiling. It is primarily needed by researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and metabolomics fields for precise biomarker quantification and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous n-butyrylglycine in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolomics Research: Used in stable isotope dilution assays to study metabolic pathways, particularly those related to fatty acid oxidation and inborn errors of metabolism.
• Clinical Diagnostics: Enables precise measurement of n-butyrylglycine levels for the diagnosis and monitoring of disorders such as short-chain acyl-CoA dehydrogenase (SCAD) deficiency.
• Pharmaceutical Development: Supports pharmacokinetic and pharmacodynamic studies by tracking drug-induced changes in specific metabolite concentrations.
• Biomarker Validation: Serves as a critical reference material in the development and validation of clinical biomarker assays.
• Quality Control & Method Development: Used in analytical laboratories to develop, validate, and ensure the ongoing precision of mass spectrometric methods.

Basic Information

Product Name	n-Butyrylglycine-2,2-D2
CAS No.	1219799-10-6
Molecular Formula	C6H9D2NO3
Molecular Weight	147.17 g/mol (for deuterated form)
Synonyms	Butyrylglycine-2,2-d2; 2-[(1-Oxobutyl)amino]acetic-2,2-d2 acid; N-Butyrylglycine-d2 (2,2); Glycine, N-(1-oxobutyl)-, 2,2-d2; Deuterated n-Butyrylglycine; Butyrylglycine Internal Standard; SCAD Biomarker Standard-d2; 2-(Butyramid)acetic-2,2-d2 acid
EINECS	Contact for details

Quality Control

Every batch of n-Butyrylglycine-2,2-D2 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and mass spectrometry to confirm identity, assay, and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.