Description

Propafenone (D7 Hydrochloride) is a deuterated internal standard of the Class IC antiarrhythmic drug, propafenone hydrochloride, specifically designed for high-precision analytical applications. This compound is essential for ensuring accurate quantification and method validation in pharmacokinetic and bioanalytical studies, where precision and reliability are paramount. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and stability studies.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Critical component in quantitative bioanalysis for the accurate measurement of propafenone and its metabolites in biological matrices such as plasma, serum, and urine.
• Essential for conducting pharmacokinetic (PK) and bioavailability studies in both clinical and preclinical research settings.
• Used in drug metabolism and disposition (DMPK) studies to track and quantify the parent drug.
• Supports method development and validation in regulatory-compliant analytical laboratories.
• Applied in quality control and impurity profiling of propafenone hydrochloride active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Propafenone (D7 Hydrochloride)
CAS No.	1219799-06-0
Molecular Formula	C21H20D7ClNO2 • HCl
Molecular Weight	406.40 g/mol (approx.)
Synonyms	Propafenone-d7 Hydrochloride; 1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d7 Hydrochloride; 2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d7 Hydrochloride; (±)-Propafenone-d7 Hydrochloride; Propafenone (heptadeuterated) Hydrochloride; Internal Standard for Propafenone; Rytmonorm-d7 Hydrochloride; SA 79-d7 Hydrochloride
EINECS	Contact for details

Quality Control

Our Propafenone (D7 Hydrochloride) is manufactured under controlled conditions to meet the exacting standards required for analytical reference materials. Each batch undergoes rigorous quality testing, including chromatographic purity and isotopic enrichment verification, to ensure consistency and reliability. Certificates of Analysis (COA) detailing specific results for identity, purity (by HPLC), and isotopic purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.