Description

Ondansetron-D5 (Methylimidazole-D5) is a deuterated internal standard of the antiemetic drug ondansetron, specifically labeled on the methylimidazole moiety. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and quality control. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical manufacturers engaged in method development, pharmacokinetic studies, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of ondansetron in biological matrices (e.g., plasma, serum) during bioanalytical studies.
• Pharmaceutical R&D: Used in method development and validation for drug substance and drug product analysis, ensuring regulatory compliance for assays.
• Metabolite Studies: Aids in the identification and quantification of ondansetron metabolites in ADME (Absorption, Distribution, Metabolism, and Excretion) research.
• Quality Control & Stability Testing: Employed in impurity profiling and stability-indicating assay methods to monitor ondansetron degradation products.
• Forensic & Clinical Toxicology: Facilitates accurate measurement of ondansetron levels in forensic and clinical toxicology applications.

Basic Information

Product Name	Ondansetron-D5 (Methylimidazole-D5)
CAS No.	1219798-86-3
Molecular Formula	C18H14D5ClN3O
Molecular Weight	314.83 g/mol (for C18H14D5ClN3O)
Synonyms	1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl-d5)methyl]-4H-carbazol-4-one; Ondansetron-d5; Ondansetron (methyl-d5); GR 38032F-d5; Zofran-d5; 1H-Imidazole, 2-methyl-1-[[(1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-ylidene)methyl]-d5]; Deuterated Ondansetron Internal Standard
EINECS	Contact for details

Quality Control

Our Ondansetron-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.