Description

(±)-n-2-Methylbutyryl-D9-Glycine CAS NO 1219798-77-2 is a high-purity, deuterium-labeled (D9) derivative of the branched-chain amino acid metabolite 2-methylbutyrylglycine. This compound serves as a critical stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry. It is primarily utilized by analytical laboratories and research institutions in the fields of clinical diagnostics, metabolomics, and inborn errors of metabolism research to ensure accurate measurement and method validation.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Essential for the accurate quantification of endogenous 2-methylbutyrylglycine in biological samples like blood, urine, and plasma.
• Clinical Diagnostics & Newborn Screening: Used in assays for diagnosing disorders of branched-chain amino acid metabolism, such as 2-methylbutyryl-CoA dehydrogenase deficiency (SBCAD deficiency).
• Metabolomics & Biomarker Research: Enables precise profiling of acyl-glycine metabolites in studies investigating metabolic pathways and disease states.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (CLIA, ISO 15189).
• Quality Control in Pharmaceutical Research: Supports bioanalytical studies for drug metabolism and pharmacokinetics (DMPK) where related metabolites are monitored.
• Reference Material for Certified Standards: Serves as a primary component in the preparation of certified reference materials (CRMs) and calibration standards for clinical laboratories.

Basic Information

Product Name	(±)-n-2-Methylbutyryl-D9-Glycine
CAS No.	1219798-77-2
Molecular Formula	C7H4D9NO3
Molecular Weight	~177.23 g/mol
Synonyms	2-Methylbutyryl-D9-glycine; D9-2-Methylbutyrylglycine; 2-Methylbutanoyl-D9-glycine; (RS)-2-Methylbutyryl-D9-glycine; N-(2-Methyl-1-oxobutyl-D9)glycine; Deuterated 2-MBG; SBCAD Deficiency Deuterated Internal Standard; 2-Methylbutyrylglycine-d9
EINECS	Contact for details

Quality Control

Every batch of (±)-n-2-Methylbutyryl-D9-Glycine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure it meets the high standards required for critical analytical applications. A Certificate of Analysis (COA) detailing specifications such as isotopic purity (D9 enrichment ≥98%), chemical purity (by HPLC), and identity confirmation is supplied with each shipment. Our quality commitment supports compliance in regulated laboratory environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D9 Enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.