Description

4-Methoxyphenyl-D4-Acetonitrile is a deuterium-labeled isotopologue of 4-methoxyphenylacetonitrile, a key synthetic intermediate. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing superior accuracy in analytical methods by compensating for matrix effects and instrument variability. It is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced material science sectors who require precise quantification and metabolic pathway tracing.

Application

• Internal Standard for LC-MS/MS: Used in the quantitative bioanalysis of pharmaceuticals and their metabolites to ensure data accuracy and regulatory compliance.
• Deuterated Building Block: Serves as a precursor in the synthesis of deuterium-labeled drug candidates for pharmacokinetic and metabolic stability studies.
• Metabolic Research: Enables precise tracing of biochemical pathways in both in vitro and in vivo studies.
• Analytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in regulated environments.
• Agrochemical Analysis: Applied in the quantification of pesticides, herbicides, and their environmental degradation products.
• Forensic Toxicology: Supports accurate identification and quantification of substances in complex biological matrices.

Basic Information

Product Name	4-Methoxyphenyl-D4-Acetonitrile
CAS No.	1219798-74-9
Molecular Formula	C9H5D4NO
Molecular Weight	151.21 g/mol
Synonyms	(4-Methoxyphenyl)-d4-acetonitrile; p-Methoxyphenyl-d4-acetonitrile; 4-Methoxyphenylacetonitrile-d4; (4-Methoxyphenyl)acetonitrile-d4; 2-(4-Methoxyphenyl)acetonitrile-d4; [D4]-4-Methoxyphenylacetonitrile; 2-(4-Methoxyphenyl)-1,1,2,2-d4-acetonitrile; p-Anisyl-d4-acetonitrile
EINECS	Contact for details

Quality Control

Our 4-Methoxyphenyl-D4-Acetonitrile is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and GC-MS, to confirm identity, chemical purity, and deuterium enrichment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which could affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.