Description

1-Bromo-3,5-Difluorobenzene-D3 is a deuterated aromatic building block of significant importance in advanced chemical synthesis and research. This isotopically labeled compound is specifically valued for its utility in mechanistic studies, metabolic pathway tracing, and as a non-radioactive tracer in pharmaceutical development. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for applications requiring precise isotopic labeling.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the development of novel Active Pharmaceutical Ingredients (APIs), particularly in medicinal chemistry for creating deuterium-labeled drug candidates with potentially improved metabolic profiles.
• Metabolic & Mechanistic Studies: Used as a stable isotopic tracer in Drug Metabolism and Pharmacokinetics (DMPK) studies to elucidate metabolic pathways and reaction mechanisms without the use of radioisotopes.
• Agrochemical Research: Serves as a building block in the synthesis of advanced, labeled agrochemicals for environmental fate and metabolism studies.
• Material Science Precursor: Employed in the synthesis of specialized deuterated polymers, liquid crystals, and organic electronic materials where isotopic purity affects physical properties.
• NMR Spectroscopy Standard: Acts as an internal standard or a reference compound in Nuclear Magnetic Resonance (NMR) spectroscopy due to its distinct spectral signature.
• Organic Synthesis Building Block: Utilized in various cross-coupling reactions (e.g., Suzuki, Stille) to introduce a difluorinated, brominated aryl moiety with isotopic labeling into complex molecular architectures.

Basic Information

Item	Detail
Product Name	1-Bromo-3,5-Difluorobenzene-D3
CAS No.	1219798-73-8
Molecular Formula	C6HD3BrF2
Molecular Weight	195.01 g/mol (approx.)
Synonyms	3,5-Difluorobromobenzene-D3; 3,5-Difluoro-1-bromobenzene-D3; Benzene-D3, 1-bromo-3,5-difluoro-; (2,4,6-Trideuterio)-3,5-difluorobromobenzene; 1-Bromo-3,5-difluoro-2,4,6-trideuteriobenzene; 3,5-Difluorophenyl-D3 bromide; Bromo-3,5-difluorobenzene (deuterated)
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3,5-Difluorobenzene-D3 is produced and analyzed under strict quality protocols to ensure high isotopic and chemical purity, critical for research and development applications. Our quality assurance includes comprehensive analytical testing, and a detailed Certificate of Analysis (COA) is provided with each shipment, documenting parameters such as chemical purity, isotopic enrichment (D%), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR / NMR)	Conforms to structure
Purity (GC / HPLC)	≥ 98.0% (Area %)
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.