Description

n-Butyl 4-Hydroxybenzoate-2,3,5,6-D4 is a deuterium-labeled analog of butylparaben, a common preservative and analytical standard. This compound matters for its critical role as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of its non-deuterated counterpart in complex matrices. It is primarily needed by analytical laboratories, pharmaceutical R&D teams, and chemical manufacturers engaged in method development, pharmacokinetic studies, and quality control for preservative systems.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Essential for stable isotope dilution assays to quantify butylparaben in biological, environmental, and product samples.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of parabens.
• Method Development and Validation: Serves as a critical reference material for developing and validating robust analytical methods in compliance with ICH and FDA guidelines.
• Cosmetic and Personal Care Product Analysis: Enables accurate monitoring of butylparaben levels in formulations for safety and regulatory compliance.
• Environmental Monitoring: Used to detect and quantify trace levels of parabens in water and soil samples.
• Food Safety Testing: Applied in the analysis of preservatives in food products and packaging materials.
• Isotopic Tracer Studies: Facilitates mechanistic studies in chemical and biochemical research pathways.

Basic Information

Product Name	n-Butyl 4-Hydroxybenzoate-2,3,5,6-D4
CAS No.	1219798-67-0
Molecular Formula	C11H10D4O3
Molecular Weight	~198.24 g/mol
Synonyms	Butylparaben-d4; Butyl 4-hydroxybenzoate-2,3,5,6-d4; Deuterated Butylparaben; Butyl Paraben D4; n-Butyl p-hydroxybenzoate-d4; Butyl 4-hydroxybenzoate (phenyl-D4); Butyl parahydroxybenzoate-d4; Butoben-d4
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing lot-specific data are provided and traceable to in-house reference materials. We support compliance with GMP/GLP principles for research and quality control laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.