Description

4-Piperidine-D9-Carboxylic Acid is a deuterium-labeled isotopologue of the versatile piperidinecarboxylic acid building block. This high-purity labeled compound is critical for applications requiring precise metabolic and pharmacokinetic studies, offering enhanced detection sensitivity and stability. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery and development.

Application

• Deuterated Internal Standards for quantitative LC-MS and GC-MS analysis in bioanalytical and pharmacokinetic studies.
• Metabolic Pathway Tracing in drug discovery to investigate the biotransformation and fate of active pharmaceutical ingredients (APIs).
• Precursor for Labeled Pharmaceutical Intermediates in the synthesis of deuterated drug candidates aimed at improving metabolic stability.
• Mechanistic Studies in medicinal chemistry, utilizing the kinetic isotope effect (KIE) to probe reaction mechanisms.
• Stable Isotope Labeling for use in NMR spectroscopy as a non-radioactive tracer in complex biological systems.
• Quality Control Reference Material for ensuring accuracy and precision in analytical method development and validation.

Basic Information

Product Name	4-Piperidine-D9-Carboxylic Acid
CAS No.	1219798-43-2
Molecular Formula	C6HD9NO2
Molecular Weight	130.20 g/mol (approx.)
Synonyms	Piperidine-4-carboxylic acid-d9; 4-Piperidinecarboxylic acid-d9; Isonipecotic acid-d9; 4-Carboxypiperidine-d9; NSC 73651-d9; (Perdeuterated) 4-Piperidinecarboxylic Acid; Hexadeutero-4-piperidinecarboxylic Acid (partial); 4-Piperidine-D9-Carboxylic Acid CAS NO 1219798-43-2
EINECS	Contact for details

Quality Control

Our 4-Piperidine-D9-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to verify chemical identity, isotopic purity (D-enrichment), and chemical purity. Certificates of Analysis (COA) with detailed specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.