Description

Tetrahydro-4H-Pyran-4-Ol-3,3,4,5,5-D5 is a deuterated derivative of tetrahydro-4H-pyran-4-ol, a key heterocyclic building block. This high-purity, isotopically labeled compound is essential for advanced research and development where precise molecular tracking is required. It is primarily utilized by pharmaceutical, agrochemical, and academic research laboratories engaged in metabolic studies, reaction mechanism elucidation, and the synthesis of novel deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: A critical precursor in the synthesis of deuterium-labeled drug candidates for improved metabolic stability and pharmacokinetic studies.
• Metabolic Pathway Tracer: Used in mass spectrometry-based research to trace and quantify metabolic pathways in biological systems.
• NMR Spectroscopy Internal Standard: Serves as a valuable internal standard or shift reagent in Nuclear Magnetic Resonance (NMR) spectroscopy due to its distinct spectral signature.
• Mechanistic Organic Chemistry Studies: Enables detailed investigation of reaction mechanisms, including kinetic isotope effects (KIE), in organic synthesis.
• Agrochemical Research: Employed in the development of novel, labeled agrochemicals for environmental fate and metabolism studies.
• Material Science Research: Used in the synthesis of specialty polymers and advanced materials where deuterium incorporation modifies physical properties.

Basic Information

Item	Details
Product Name	Tetrahydro-4H-Pyran-4-Ol-3,3,4,5,5-D5
CAS No.	1219795-46-6
Molecular Formula	C5H5D5O2
Molecular Weight	107.16 g/mol (approx.)
Synonyms	3,3,4,5,5-Pentadeutero-tetrahydro-4H-pyran-4-ol; Tetrahydro-4H-pyran-4-ol-d5; 4-Hydroxytetrahydropyran-d5; 4-Hydroxyoxane-d5; Deuterated THP alcohol; Oxan-4-ol-d5; Perdeuterated THP-4-ol (on pyran ring); 4-Hydroxy-1-oxacyclohexane-d5
EINECS	Contact for details

Quality Control

Our Tetrahydro-4H-Pyran-4-Ol-3,3,4,5,5-D5 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by GC/HPLC), isotopic enrichment (by NMR/MS), and identity confirmation. We support development and commercial projects requiring materials that meet stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (GC / HPLC)	≥ 98.0% (Area %)
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.