Description

Ethyl-D5 Methanesulfonate is a deuterated isotopologue of ethyl methanesulfonate, where five hydrogen atoms are replaced by deuterium, making it a valuable stable isotope-labeled compound. This high-purity standard is essential for applications requiring precise internal standards in quantitative mass spectrometry, eliminating interference from endogenous compounds. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for method development, metabolic studies, and quality control.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of ethyl methanesulfonate (EMS) in pharmaceutical products via LC-MS or GC-MS.
• Use in metabolic pathway tracing and pharmacokinetic studies within drug discovery and development.
• Critical for genotoxicity and impurity testing in compliance with ICH Q3A/B guidelines for genotoxic impurities.
• Application in analytical method development and validation to ensure specificity and accuracy.
• Utilization in chemical synthesis research as a deuterated reagent or intermediate.
• Employed in environmental and forensic analysis for the detection and quantification of alkylating agents.

Basic Information

Product Name	Ethyl-D5 Methanesulfonate
CAS No.	1219795-44-4
Molecular Formula	C3D5HO3S
Molecular Weight	158.21 g/mol
Synonyms	Ethyl-d5 Methanesulfonate; [2H5]-Ethyl Methanesulfonate; Ethyl Methanesulfonate-d5; Deuterated Ethyl Methanesulfonate; EMS-d5; Methanesulfonic Acid Ethyl-d5 Ester; (2,2,2-Trideuteroethyl) (trideuteromethyl) Sulfonate
EINECS	Contact for details

Quality Control

Our Ethyl-D5 Methanesulfonate is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant standards for high-purity reference materials, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.