Description

Ethyl 1-Piperazine-D8 Acetate is a high-purity, deuterium-labeled derivative of piperazine acetate, serving as a critical stable isotope-labeled internal standard. This compound is essential for ensuring analytical accuracy and precision in quantitative mass spectrometry, eliminating matrix effects and instrument variability. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Quantitative Bioanalysis: Used as a stable isotope-labeled internal standard (SIL-IS) in LC-MS/MS methods for the accurate quantification of piperazine-based drug candidates and their metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) by correcting for sample preparation and ionization efficiency variations.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles, aiding in the understanding of metabolic pathways and potential drug-drug interactions.
• Method Development and Validation: Critical for developing robust, sensitive, and regulatory-compliant (e.g., FDA, EMA) bioanalytical assays, ensuring data integrity for preclinical and clinical trials.
• Quality Control in API Manufacturing: Can be employed in analytical methods to monitor the purity and stability of active pharmaceutical ingredients (APIs) containing the piperazine moiety.

Basic Information

Product Name	Ethyl 1-Piperazine-D8 Acetate
CAS No.	1219795-32-0
Molecular Formula	C8D8H8N2O2
Molecular Weight	180.24 g/mol
Synonyms	1-Piperazineacetic acid, ethyl ester-d8; Ethyl piperazine-1-acetate-d8; Ethyl (piperazin-1-yl)acetate-d8; Deuterated Ethyl 1-Piperazineacetate; Ethyl 1-Piperazineacetate-d8; Piperazine-1-acetic acid ethyl ester-d8; Ethyl N-(aminoethyl)glycinate-d8 derivative
EINECS	Contact for details

Quality Control

Every batch of Ethyl 1-Piperazine-D8 Acetate is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D-content), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with customer specifications. Our quality commitment supports applications requiring data for regulatory submissions (FDA, ICH).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.