Description

2-Methylbutyryl-D9 Chloride is a high-purity, deuterium-labeled isotopologue of 2-methylbutyryl chloride, a key acylating agent. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing sectors who require precise quantification of metabolites or related compounds.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the accurate quantification of 2-methylbutyric acid or its derivatives in complex biological matrices like plasma, urine, or tissue samples.
• Pharmaceutical Research & Metabolism Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to trace drug metabolites, enabling precise bioanalytical method development and validation.
• Agrochemical Analysis: Facilitates the reliable measurement of pesticide or herbicide degradation products in environmental and food safety testing.
• Biochemical Research: Serves as a specialized reagent for probing enzymatic mechanisms involving short-chain fatty acid metabolism or for synthesizing deuterium-labeled probes.
• Chemical Synthesis Intermediate: Acts as a deuterated building block for the synthesis of more complex labeled compounds for research purposes.

Basic Information

Product Name	2-Methylbutyryl-D9 Chloride
CAS No.	1219795-10-4
Molecular Formula	C5D9ClO
Molecular Weight	134.64 g/mol (for D9 isotopologue)
Synonyms	2-Methylbutanoyl-D9 chloride; Isobutylacetyl-D9 chloride; 2-Methylbutyroyl-D9 chloride; Deuterated 2-methylbutyryl chloride (D9); (2-Methylbutanoyl-D9) chloride; α-Methylbutyryl-D9 chloride; 2-Methyl-D9-butyryl chloride; 1219795-10-4
EINECS	Contact for details

Quality Control

Every batch of 2-Methylbutyryl-D9 Chloride is manufactured and analyzed under strict quality management systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR, GC-MS, and HPLC analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D9, typically >98 atom % D), chemical purity, and identity confirmation is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its nature as a strong acid/organic solvent, it should be kept away from heat, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Handle and store under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 97.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.