Description

Cyclopropane-D5-Carbonyl Chloride is a deuterated derivative of cyclopropanecarbonyl chloride, where five hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications requiring precise molecular tracking and reduced metabolic interference in research. It serves as a valuable synthetic intermediate for pharmaceutical and agrochemical research, particularly in the development of deuterated active pharmaceutical ingredients (d-APIs). This compound is essential for scientists and manufacturers in medicinal chemistry, analytical chemistry, and advanced material science.

Application

• Deuterated Active Pharmaceutical Ingredient (d-API) Synthesis: A key building block for creating deuterium-labeled drug candidates to study pharmacokinetics, metabolic pathways, and to enhance drug stability.
• Medicinal Chemistry Research: Used as a specialized reagent in the synthesis of isotopically labeled analogs for structure-activity relationship (SAR) studies and bioisosteric replacement.
• Analytical Standard & Mass Spectrometry: Employed as an internal standard in quantitative LC-MS and GC-MS analysis to ensure accuracy and reliability in bioanalytical and environmental testing.
• Agrochemical Development: Utilized in the research and synthesis of novel, labeled pesticides and herbicides to study environmental fate and degradation.
• NMR Spectroscopy Solvent & Reagent: Acts as a reagent or precursor for preparing deuterated solvents and shift reagents used in nuclear magnetic resonance spectroscopy.
• Organic Synthesis & Material Science: Serves as an acylating agent in advanced organic synthesis for introducing the cyclopropane-D5-carbonyl moiety into complex molecules and polymers.

Basic Information

Product Name	Cyclopropane-D5-Carbonyl Chloride
CAS No.	1219794-96-3
Molecular Formula	C4D5ClO
Molecular Weight	109.56 g/mol (for C4D5ClO)
Synonyms	Cyclopropanecarbonyl-D5 chloride; (Cyclopropyl-D5)-carbonyl chloride; Perdeuterocyclopropanecarbonyl chloride; Cyclopropanecarboxylic-D5 acid chloride; Cyclopropanoyl-D5 chloride; Deuterated Cyclopropanecarbonyl Chloride; d5-Cyclopropanecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Cyclopropane-D5-Carbonyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ²H, ¹³C), GC-MS, and FTIR to confirm structural identity, isotopic purity (D-enrichment), and chemical purity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.