Description

Phenylbutazone-D10 (Diphenyl-D10) is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, where ten hydrogen atoms are replaced by deuterium. This high-purity internal standard is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and analytical chemistry sectors who require precise quantification of phenylbutazone in complex matrices.

Application

• Internal Standard for LC-MS/MS: Primary use as a deuterated internal standard for the precise quantification of phenylbutazone in bioanalytical studies, pharmacokinetic research, and residue testing.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of the parent compound and its metabolites.
• Veterinary Drug Analysis: Critical for developing and validating sensitive methods to detect and quantify phenylbutazone residues in food-producing animals to ensure food safety and regulatory compliance.
• Forensic and Doping Control: Employed in confirmatory testing protocols in anti-doping laboratories for equine and human sports.
• Method Development & Validation: Serves as a key component in establishing robust, accurate, and reproducible analytical methods in compliance with guidelines like ICH, FDA, and EMA.
• Environmental Monitoring: Potential use in trace analysis of pharmaceutical pollutants in environmental water samples.

Basic Information

Item	Detail
Product Name	Phenylbutazone-D10 (Diphenyl-D10)
CAS No.	1219794-69-0
Molecular Formula	C19D10H10N2O2
Molecular Weight	318.39 g/mol
Synonyms	4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione-d10; Phenylbutazone-d10; 1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione-d10; Diphenyl-D10; Deuterated Phenylbutazone; Phenylbutazone (phenyl-D5, butyl-D5); [D10]-Phenylbutazone; Butazolidin-d10
EINECS	Contact for details

Quality Control

Every batch of Phenylbutazone-D10 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. Certificates of Analysis (COA) are supplied with each shipment, detailing key parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality commitment ensures consistency and reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.