Description

n-Methyl-D3-Glycine-2,2-D2 Hcl is a high-purity, isotopically labeled derivative of glycine, specifically designed for advanced research and analytical applications. This compound is critical for internal standard use in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of glycine and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolic Pathway Tracing: Used in stable isotope labeling experiments (SIL) to investigate amino acid metabolism, protein synthesis, and neurotransmitter dynamics.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Biomarker Discovery & Validation: Supports high-throughput screening and validation of disease biomarkers in metabolomics and clinical research.
• Neurochemical Research: Employed in studies focusing on glycine's role as an inhibitory neurotransmitter and its receptor interactions.
• Quality Control Reference Material: Serves as a certified reference standard for method development and validation in analytical laboratories.

Basic Information

Product Name	n-Methyl-D3-Glycine-2,2-D2 Hcl
CAS No.	1219794-62-3
Molecular Formula	C3D5H4NO2 • HCl
Molecular Weight	138.59 g/mol (for monoisotopic form)
Synonyms	N-Methyl-d3-glycine-2,2-d2 hydrochloride; (2,2-Dideutero-N-(trideuteriomethyl)glycine) hydrochloride; Sarcosine-d5 hydrochloride; N-Methylamino-d5-acetic acid hydrochloride; Deuterated Sarcosine HCl; Methyl-d3-glycine-2,2-d2 HCl; Glycine, N-methyl-d3-2,2-d2, hydrochloride; Internal Standard for Glycine Quantification
EINECS	Contact for details

Quality Control

Every batch of n-Methyl-D3-Glycine-2,2-D2 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to meet the exacting standards required for research and regulatory submission support. A detailed Certificate of Analysis (COA) providing batch-specific data for isotopic purity, chemical purity, and residual solvents is supplied with each order.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.