Description

(4Ar,8S,8Ar)-2-Benzyl-1-Oxo-1,2,3,4,4A,7,8,8A-Octahydroisoquinoline-8-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined polycyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and neurological disorder therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in process chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of complex drug candidates, especially for neurological targets.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under GMP conditions.
• Academic Research: Valuable reagent for studying organic synthesis methodologies, particularly asymmetric synthesis and heterocyclic chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(4Ar,8S,8Ar)-2-Benzyl-1-Oxo-1,2,3,4,4A,7,8,8A-Octahydroisoquinoline-8-Carboxylic Acid
CAS No.	1219703-92-0
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.34 g/mol
Synonyms	(4aR,8S,8aR)-2-Benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid; 2-Benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid (stereoisomer); (8S,4aR,8aR)-2-Benzyl-1-oxo-1,2,3,4,4a,7,8,8a-octahydroisoquinoline-8-carboxylic acid; Octahydroisoquinoline-8-carboxylic acid derivative; BOCHEM-103877; ZINC000103178946; AKOS040759506
EINECS	Contact for details

Quality Control

Our (4Ar,8S,8Ar)-2-Benzyl-1-Oxo-1,2,3,4,4A,7,8,8A-Octahydroisoquinoline-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific impurity limits is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.