Description

1-Benzyl-3-n-Cbz-Amino-2,5-Dioxo-Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group on a pyrrolidine-dione scaffold. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry and peptide mimetic research, where precise functional group manipulation is required. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Research: Serves as a constrained scaffold for designing protease inhibitors and other bioactive peptide analogs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore new chemical entities for various therapeutic targets.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex molecules.
• Bioconjugation: Potential use in linker chemistry for antibody-drug conjugates (ADCs) due to its reactive handles.
• Academic Research: Valuable reagent in university and institutional labs for organic synthesis and methodological development.

Basic Information

Product Name	1-Benzyl-3-n-Cbz-Amino-2,5-Dioxo-Pyrrolidine
CAS No.	1219424-59-5
Molecular Formula	C19H18N2O5
Molecular Weight	354.36 g/mol
Synonyms	1-Benzyl-3-[(benzyloxy)carbonylamino]-2,5-pyrrolidinedione; 3-(Cbz-Amino)-1-benzyl-2,5-pyrrolidinedione; N-Cbz-3-Amino-1-benzyl-2,5-diketopyrrolidine; 1-Benzyl-3-(N-carbobenzyloxyamino)-2,5-dioxopyrrolidine; 3-[(Benzyloxycarbonyl)amino]-1-benzylpyrrolidine-2,5-dione; 1-Benzyl-3-(Cbz-NH)-2,5-dioxopyrrolidine; N-Carbobenzyloxy-3-amino-1-benzyl-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3-n-Cbz-Amino-2,5-Dioxo-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.