Description

Clopidogrel Amide-D4 is a high-purity, isotopically labeled analog of a key pharmaceutical intermediate. This deuterated compound is essential for conducting precise and reliable bioanalytical studies, including metabolism and pharmacokinetic research. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) for use as an internal standard in mass spectrometry-based assays, ensuring accurate quantification and supporting drug development and regulatory submissions.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for bioanalysis.
• Metabolite identification and profiling studies in preclinical and clinical research.
• Quantitative analysis of Clopidogrel and its metabolites in biological matrices (e.g., plasma, serum).
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development.
• Method development and validation in accordance with FDA, EMA, and ICH guidelines.
• Use in doping control and forensic analysis for precise substance identification.
• Stability studies and impurity profiling of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Clopidogrel Amide-D4
CAS No.	1219423-91-2
Molecular Formula	C15H12D4ClNO2S
Molecular Weight	322.83 g/mol (for D4 isotopologue)
Synonyms	Methyl (2S)-2-(2-Chlorophenyl)-2-(4,5,6,7-tetradeutero-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)acetate; Clopidogrel Amide-d4; Clopidogrel-d4 Amide; (+)-(S)-Clopidogrel Amide-d4; (S)-Clopidogrel Amide-d4; Clopidogrel Carboxylic Acid Amide-d4; Isotopically Labeled Clopidogrel Intermediate-d4
EINECS	Contact for details

Quality Control

Every batch of Clopidogrel Amide-D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of analytical and pharmaceutical research. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for isotopic enrichment, chemical purity, and identity confirmation via NMR and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.