Description

2-n-Boc-Amino-3-(4-Tetrahydrothiopyranyl)Propionic Acid is a sophisticated, non-proteinogenic amino acid derivative featuring a Boc-protected amine and a tetrahydrothiopyranyl side chain. This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of unique conformational and functional properties. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of new drug candidates, particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate constrained, sulfur-containing amino acid analogs.
• Chemical Biology Probes: Serves as a building block for creating specialized probes to study enzyme mechanisms and protein-protein interactions.
• Library Synthesis: Employed in combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and medicinal chemistry.
• Process Development: Acts as a starting material or intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-n-Boc-Amino-3-(4-Tetrahydrothiopyranyl)Propionic Acid
CAS No.	1219420-46-8
Molecular Formula	C13H23NO4S
Molecular Weight	289.39 g/mol
Synonyms	Boc-4-Thp-Ala-OH; 2-[(tert-Butoxycarbonyl)amino]-3-(tetrahydro-2H-thiopyran-4-yl)propanoic acid; tert-Butyl (1-carboxy-2-(tetrahydro-2H-thiopyran-4-yl)ethyl)carbamate; 3-(Tetrahydro-2H-thiopyran-4-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; Boc-4-thiopyranylalanine; N-Boc-3-(4-tetrahydrothiopyranyl)-L-alanine; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(thian-4-yl)propanoic acid (for enantiomer); 4-Thp(Boc)-OH
EINECS	Contact for details

Quality Control

Our production of 2-n-Boc-Amino-3-(4-Tetrahydrothiopyranyl)Propionic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing HPLC purity, chiral purity (where applicable), and other critical parameters are provided to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.