Description

Fmoc-Dl-6-Methoxy-1,2,3,4-Tetrahydronorharman-1-Carboxylic Acid CAS NO 1219416-81-5 is a specialized, high-purity Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex peptide and peptidomimetic structures, particularly those targeting neurological research. This compound is essential for research and development laboratories in the pharmaceutical and biotechnology sectors, where it is used to develop novel therapeutic agents and probe biochemical pathways.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides containing the norharman (β-carboline) scaffold.
• Medicinal Chemistry Research: Used in the design and synthesis of novel drug candidates targeting central nervous system (CNS) disorders, cancer, and other therapeutic areas.
• Peptidomimetic Development: Facilitates the creation of metabolically stable analogs of natural peptides for enhanced drug-like properties.
• Chemical Biology Probes: Employed to synthesize labeled or tagged molecules for studying enzyme interactions and receptor binding.
• Academic & Institutional R&D: A vital reagent for universities and research institutes exploring heterocyclic chemistry and peptide science.
• Custom Synthesis Services: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	Fmoc-Dl-6-Methoxy-1,2,3,4-Tetrahydronorharman-1-Carboxylic Acid
CAS No.	1219416-81-5
Molecular Formula	C25H24N2O5
Molecular Weight	432.47 g/mol
Synonyms	Fmoc-6-MeO-THN-OH; Fmoc-6-Methoxy-1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid; Fmoc-DL-6-methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-methoxy-1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid; DL-Fmoc-6-methoxynorharman-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-6-Methoxy-1,2,3,4-Tetrahydronorharman-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.