Description

Rac α-Aminoadipic Acid-D4 CAS NO 1219407-94-9 is a high-purity, deuterium-labeled isotopologue of α-aminoadipic acid, a key intermediate in lysine metabolism. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, ensuring unparalleled analytical accuracy and reproducibility. It is critically needed by researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for advanced metabolic studies, pharmacokinetic analysis, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for analyzing endogenous α-aminoadipic acid levels in biological matrices (plasma, urine, tissue).
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) to elucidate the lysine degradation pathway and related metabolic fluxes in disease models, such as cancer and neurological disorders.
• Pharmaceutical R&D: Critical for accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies of drug candidates targeting metabolic enzymes or pathways involving α-aminoadipate.
• Biomarker Research & Validation: Enables precise quantification of α-aminoadipic acid as a potential biomarker for conditions like diabetes, cardiovascular diseases, and glutaric aciduria type I.
• Diagnostic Assay Development: Serves as a calibrator in the development of clinical diagnostic kits for inborn errors of metabolism.
• NMR Spectroscopy: Provides a non-radioactive tracer for metabolic studies using deuterium NMR, allowing for detailed structural and dynamic analysis.

Basic Information

Product Name	Rac α-Aminoadipic Acid-D4
CAS No.	1219407-94-9
Molecular Formula	C6D4H5NO4
Molecular Weight	167.15 g/mol (deuterated form)
Synonyms	(±)-2-Amino-1,1,6,6-d4-adipic Acid; DL-α-Aminoadipic Acid-d4; 2-Aminoadipic Acid-d4; H-DL-Aad-OH-d4; 2-Aminohexanedioic Acid-d4; α-Aminoadipic Acid-d4; rac-Aminoadipic Acid-d4; Deuterated α-Aminoadipate
EINECS	Contact for details

Quality Control

Every batch of Rac α-Aminoadipic Acid-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific data on purity, isotopic enrichment, and solvent residues to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.