Description

2,2-Dideuterio-2-[[1,1-Dideuterio-2-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)-2-Hydroxyethyl]Amino]-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanol is a deuterated derivative of a chroman-based ethanolamine compound, serving as a critical stable isotope-labeled internal standard. Its primary value lies in enabling precise quantitative analysis and metabolic studies in complex biological matrices, where it compensates for matrix effects and instrument variability. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors, particularly for the development and validation of bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the accurate quantification of its non-deuterated counterpart or related chroman derivatives in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Tracing: Facilitates the investigation of drug metabolism and disposition (DMPK) studies due to its isotopic label, allowing for differentiation from endogenous compounds.
• Pharmaceutical Impurity Profiling: Employed as a reference standard to identify and quantify process-related impurities and degradation products during drug substance and drug product development.
• Method Development & Validation: A critical tool for developing, optimizing, and validating sensitive and specific analytical methods in compliance with ICH and FDA guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Applied in high-precision IDMS techniques to achieve superior accuracy in concentration measurements.
• Chemical Reference Material: Serves as a certified reference material (CRM) or high-purity standard for calibrating analytical instruments and ensuring data integrity.

Basic Information

Item	Details
Product Name	2,2-Dideuterio-2-[[1,1-Dideuterio-2-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)-2-Hydroxyethyl]Amino]-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanol
CAS No.	1219407-55-2
Molecular Formula	C22H24D4F2NO4
Molecular Weight	Contact for details
Synonyms	1-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[1,1-dideuterio-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-2,2-dideuterioethanol; Deuterated Chroman Ethanolamine Derivative; [D4]-Labeled Chroman Analog; 6-Fluoro-3,4-dihydro-2H-chromen-2-ethanol, deuterated amino derivative; Stable Isotope-Labeled Internal Standard 1219407-55-2
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured and analyzed under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, isotopic enrichment, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, assay, and isotopic purity is provided with each shipment, ensuring traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.