Description

(-2-Acetylaminobutanoic Acid-D3 is a stable isotope-labeled analog of N-Acetyl-DL-norvaline, where three hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for creating internal standards in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical workflows. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and metabolomics fields for method development, pharmacokinetic studies, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical assays for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolomics Research: Used as a tracer in metabolic pathway analysis and flux studies to investigate biochemical mechanisms.
• Pharmaceutical Impurity Analysis: Enables precise detection and quantification of process-related impurities and degradants in Active Pharmaceutical Ingredient (API) batches.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the gold standard for accurate quantification of amino acid derivatives in complex matrices.
• Proteomics and Peptide Chemistry: Acts as a building block for synthesizing isotopically labeled peptides for mass spectrometry-based protein quantification.
• Environmental and Food Safety Testing: Facilitates high-accuracy analysis of chemical residues where labeled internal standards are required for regulatory compliance.

Basic Information

Item	Detail
Product Name	(-2-Acetylaminobutanoic Acid-D3
CAS No.	1219397-36-0
Molecular Formula	C6H8D3NO3
Molecular Weight	148.17 g/mol (approx.)
Synonyms	N-Acetyl-DL-norvaline-d3; 2-(Acetylamino)pentanoic-3,4,4-d3 Acid; 2-Acetamidopentanoic-3,4,4-d3 Acid; DL-2-Acetamidopentanoic-3,4,4-d3 Acid; N-Acetylnorvaline-d3; Ac-DL-Nva-d3; (RS)-2-Acetamidopentanoic-3,4,4-d3 Acid; Deuterated N-Acetyl-DL-norvaline
EINECS	Contact for details

Quality Control

Every batch of (-2-Acetylaminobutanoic Acid-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including assay, isotopic purity (D-content), and identification. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.