Description

2-Cbz-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a key chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on producing high-value active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular systems.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and isoquinoline-based peptidomimetics for enhanced metabolic stability.
• API Development: Employed in the route development and scale-up processes for new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized as a chiral building block for the preparation of enantiomerically pure compounds.
• Chemical Biology Probes: Acts as a core structure for developing molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	2-Cbz-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1219360-65-2
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	1-Carboxy-2-[(benzyloxy)carbonyl]-1,2,3,4-tetrahydro-6-hydroxyisoquinoline; 2-[(Benzyloxy)carbonyl]-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 2-Cbz-6-OH-Tic-OH; 2-Carbobenzyloxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 6-Hydroxy-2-[(phenylmethoxy)carbonyl]-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic Acid; 2-(Benzyloxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 2-Cbz-6-Hydroxy-Tic-OH; 2-Cbz-6-Hydroxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Cbz-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.