Description

Betaine-D3 Hydrochloride is a stable isotope-labeled analog of betaine hydrochloride, where three hydrogen atoms are replaced by deuterium. This high-purity compound is essential for advanced analytical and research applications requiring precise molecular tracking and quantification. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of diagnostic reagents for applications in mass spectrometry, metabolic studies, and internal standard development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of betaine and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolic Pathway Tracing: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to trace and elucidate metabolic pathways and drug metabolism mechanisms.
• Diagnostic Kit Manufacturing: A key component in the production of high-sensitivity in-vitro diagnostic (IVD) kits for assessing biomarkers related to homocysteine metabolism and cardiovascular health.
• Nutritional Research: Employed in stable isotope feeding studies to investigate choline and betaine metabolism, absorption, and utilization in clinical and animal research.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Applied in enzymatic assays and studies of methyl group transfer reactions due to its role as a methyl donor.

Basic Information

Item	Detail
Product Name	Betaine-D3 Hydrochloride
CAS No.	1219349-47-9
Molecular Formula	C5H8D3ClNO2
Molecular Weight	154.61 g/mol
Synonyms	Trimethylglycine-d3 Hydrochloride; (Carboxymethyl)trimethylammonium-d3 Chloride; Glycine Betaine-d3 Hydrochloride; N,N,N-Trimethylglycine-d3 Hydrochloride; 2-(Trimethylammonio)acetate-d3 Chloride; Lycine-d3 Hydrochloride; Oxyneurine-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Betaine-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for isotopic enrichment verification and HPLC for chemical purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on assay, isotopic purity, residual solvents, and other critical parameters to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.