Description

Methyl 5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is a high-purity, synthetically valuable organic salt, serving as a critical building block in advanced pharmaceutical research and development. Its core value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, which are essential scaffolds in modern medicinal chemistry. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel bioactive molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the tetrahydroisoquinoline core.
• Agrochemical Development: Serves as a building block for creating new active ingredients in crop protection products, such as herbicides and fungicides.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) engaged in the custom synthesis of complex organic molecules for clients.
• Academic Research: Employed in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Methyl 5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride
CAS No.	1219210-17-9
Molecular Formula	C11H13BrClNO2
Molecular Weight	306.58 g/mol
Synonyms	5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester hydrochloride; Methyl 5-bromo-3,4-dihydro-1H-isoquinoline-3-carboxylate hydrochloride; 5-Bromo-THIQ-3-COOMe·HCl; 1219210-17-9; 5-Bromotetrahydroisoquinoline-3-carboxylic acid methyl ester HCl salt
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.