Description

6-Hydroxy-2-(Methoxycarbonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific tetrahydroisoquinoline carboxylic acid structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular diseases.
• API Synthesis: Serves as a core scaffold for constructing Active Pharmaceutical Ingredients (APIs) with tetrahydroisoquinoline pharmacophores.
• Medicinal Chemistry Research: Used extensively in R&D laboratories for structure-activity relationship (SAR) studies and lead optimization processes.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Bioconjugation Chemistry: Potential use in creating drug-linker complexes for targeted therapies and antibody-drug conjugates (ADCs).

Basic Information

Product Name	6-Hydroxy-2-(Methoxycarbonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	1219199-11-7
Molecular Formula	C12H13NO5
Molecular Weight	251.24 g/mol
Synonyms	6-Hydroxy-2-(methoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-6-hydroxy-2-(methoxycarbonyl)-3-isoquinolinecarboxylic acid; Methyl 6-hydroxy-3-carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; (3S)-6-Hydroxy-2-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (for stereospecific form); THIQ-3-COOH derivative; CAS 1219199-11-7
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-2-(Methoxycarbonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.