Description

5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester is a high-value, synthetically versatile heterocyclic building block. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key precursor for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial scaffold for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable bromo and ester functional groups.
• Library Synthesis: Employed in combinatorial and parallel synthesis to create diverse chemical libraries for high-throughput screening.
• Agrochemical Development: Acts as a building block for novel active ingredients in crop protection and pest management research.
• Chemical Biology Probes: Useful for the development of molecular probes to study enzyme function and biological pathways.
• Academic Research: Serves as a starting material for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Information
Product Name	5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester
CAS No.	1219170-24-7
Molecular Formula	C11H12BrNO2
Molecular Weight	270.12 g/mol
Synonyms	Methyl 5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; 5-Bromo-3-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline; 5-Bromo-THIQ-3-COOMe; 5-Bromotetrahydroisoquinoline-3-carboxylic acid methyl ester; 5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.