Description

1-Boc-6-Methylindole-2-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected indole boronic esters. This compound is a critical building block in modern synthetic organic chemistry, valued for its stability and reactivity in cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, essential for constructing complex biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a protected precursor in the multi-step synthesis of potential drug candidates, particularly those containing functionalized indole scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific indole-based architectures.
• Material Science: Employed in the synthesis of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular structure is crucial.
• Academic & Process Chemistry: A valuable tool for methodological development and scaling up synthetic routes in academic and industrial R&D laboratories.

Basic Information

Product Name	1-Boc-6-Methylindole-2-Boronic Acid, Pinacol Ester
CAS No.	1218791-10-6
Molecular Formula	C20H28BNO4
Molecular Weight	357.26 g/mol
Synonyms	1-Boc-6-Methyl-1H-indole-2-boronic acid pinacol ester; 6-Methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]-1H-indole-2-boronic acid pinacol ester; tert-Butyl 6-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-6-methylindole-2-boronate pinacol ester; 1-(tert-Butoxycarbonyl)-6-methylindole-2-boronic acid pinacol ester; 6-Methyl-1-Boc-indole-2-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Methylindole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.