Description

[1,2,5]Oxadiazolo[3,4-B]Pyridin-6-Ylboronic Acid Pinacol Ester is a high-value, heterocyclic boronic ester building block crucial for modern synthetic chemistry. This compound matters because it enables the precise construction of complex molecular architectures through reliable cross-coupling reactions. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and development programs. Its stability as a pinacol ester makes it a preferred reagent for introducing the unique [1,2,5]oxadiazolo[3,4-b]pyridine scaffold.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting kinase inhibition and central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling: Used as a versatile boron reagent in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, enabling the attachment of the fused oxadiazole-pyridine heterocycle to aromatic and heteroaromatic systems.
• Agrochemical Research: Employed in the discovery and development of novel herbicides, fungicides, and insecticides that require complex heterocyclic cores for bioactivity.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers, where the electron-deficient heterocycle can tune electronic properties.
• Chemical Biology & Probe Development: Utilized to create molecular probes and tool compounds for studying biological pathways and protein function.
• Library Synthesis: A valuable reagent for medicinal chemistry teams engaged in high-throughput synthesis to generate diverse compound libraries for screening.

Basic Information

Item	Detail
Product Name	[1,2,5]Oxadiazolo[3,4-B]Pyridin-6-Ylboronic Acid Pinacol Ester
CAS No.	1218790-54-5
Molecular Formula	C13H16BN3O3
Molecular Weight	273.10 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,5]oxadiazolo[3,4-b]pyridine; [1,2,5]Oxadiazolo[3,4-b]pyridin-6-ylboronic acid pinacol ester; 6-(Pinacolatoboryl)-[1,2,5]oxadiazolo[3,4-b]pyridine; Furo[2,3-c]pyridazine-5-boronic acid pinacol ester (alternative ring system naming); [1,2,5]Oxadiazolo[3,4-b]pyridine-6-boronic acid pinacol ester; B-[1,2,5]Oxadiazolo[3,4-b]pyridin-6-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our [1,2,5]Oxadiazolo[3,4-B]Pyridin-6-Ylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.