Description

5-(1-Piperidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing thiophene and piperidine pharmacophores.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or precursor in the creation of conjugated polymers and organic electronic materials for OLEDs and sensors.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for target identification and validation.
• Catalyst Ligand Development: The structural motifs can be utilized to develop novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	5-(1-Piperidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester
CAS No.	1218790-44-3
Molecular Formula	C16H26BNO2S
Molecular Weight	307.26 g/mol
Synonyms	5-[(Piperidin-1-yl)methyl]thiophene-2-boronic acid pinacol ester; 2-(5-((Piperidin-1-yl)methyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(Piperidin-1-ylmethyl)thiophene-2-boronic acid pinacol ester; Thiophene-2-boronic acid, 5-[(1-piperidinyl)methyl]-, 1,1-dimethylethyl ester; Pinacol 5-(piperidin-1-ylmethyl)thiophene-2-boronate; Boronic acid, B-[5-[(1-piperidinyl)methyl]-2-thienyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-(1-Piperidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.