Description

1-Boc-5-Chloroindole-3-Boronic Acid, Pinacol Ester is a high-purity, protected boronic ester derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its primary value lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex molecular architectures with precision. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel indole-based active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-containing drug candidates, including kinase inhibitors and receptor modulators.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to attach complex aryl and heteroaryl groups to the indole scaffold.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with indole-based structures.
• Material Science: Serves as a precursor for creating functional organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the construction of bifunctional molecules for targeted protein degradation research.
• Academic & Contract Research: A valuable reagent for method development and exploring new synthetic pathways in academic and CRO laboratory settings.

Basic Information

Product Name	1-Boc-5-Chloroindole-3-Boronic Acid, Pinacol Ester
CAS No.	1218790-30-7
Molecular Formula	C19H25BClNO4
Molecular Weight	377.67 g/mol
Synonyms	5-Chloro-1-[(tert-butoxy)carbonyl]-1H-indol-3-ylboronic acid pinacol ester; 1-Boc-5-chloroindole-3-boronic acid pinacol ester; tert-Butyl 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 5-Chloro-1-Boc-indole-3-boronic acid pinacol ester; 1-Boc-5-Cl-indole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Chloroindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.