Description

8-Oxo-6,7-Dihydro-5H-Indolizine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a fused indolizine core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is essential for pharmaceutical manufacturers and R&D organizations focused on developing new therapeutic agents, including potential candidates in oncology and other specialized fields.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug molecules and novel chemical entities.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the development and scale-up of Active Pharmaceutical Ingredients (APIs) targeting specific biological pathways.
• Organic Synthesis Building Block: Utilized in academic and industrial laboratories for constructing complex heterocyclic compounds due to its reactive carboxylic acid and ketone functionalities.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	8-Oxo-6,7-Dihydro-5H-Indolizine-5-Carboxylic Acid
CAS No.	1218197-94-4
Molecular Formula	C10H9NO3
Molecular Weight	191.18 g/mol
Synonyms	5H-Indolizine-5-carboxylic acid, 6,7-dihydro-8-oxo-; 8-Oxo-5,6,7,8-tetrahydroindolizine-5-carboxylic acid; Indolizine-5-carboxylic acid, 6,7-dihydro-8-oxo-; 1218197-94-4; 8-Oxo-6,7-dihydro-5H-indolizine-5-carboxylic acid; 5-Carboxy-8-oxo-5,6,7,8-tetrahydroindolizine
EINECS	Contact for details

Quality Control

Our 8-Oxo-6,7-Dihydro-5H-Indolizine-5-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.