Description

(R)-O,o-Bis(tert-Butyldimethlsilyl)Phenylephrine is a key chiral intermediate and protected derivative of the adrenergic agent phenylephrine. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in the development of novel cardiovascular, ophthalmic, and nasal decongestant formulations.

Application

• Pharmaceutical Intermediate: A critical building block for the enantioselective synthesis of (R)-Phenylephrine and related chiral APIs.
• Asymmetric Synthesis: Used in research to develop new synthetic routes for chiral adrenergic drugs, leveraging the tert-butyldimethylsilyl (TBDMS) protecting groups.
• Process Chemistry: Serves as a high-purity intermediate in scale-up and process optimization for commercial drug manufacturing.
• Reference Standard: Employed as a chromatographic reference standard in analytical method development and quality control for phenylephrine-based products.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to develop new analogs with improved selectivity and efficacy.

Basic Information

Product Name	(R)-O,o-Bis(tert-Butyldimethlsilyl)Phenylephrine
CAS No.	1217862-07-1
Molecular Formula	C24H45NO2Si2
Molecular Weight	435.80 g/mol
Synonyms	(R)-Phenylephrine O,O-Bis-TBDMS Ether; (R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol O,O-Bis(tert-butyldimethylsilyl) Ether; (R)-O,O-Bis-TBDMS-Phenylephrine; (R)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol O,O-Bis(tert-butyldimethylsilyl) Ether; (R)-Bis-TBDMS Protected Phenylephrine; (R)-TBDMS-Phenylephrine; (R)-α-(Methylaminomethyl)-3-hydroxybenzyl alcohol O,O-Bis(tert-butyldimethylsilyl) Ether
EINECS	Contact for details

Quality Control

Our (R)-O,o-Bis(tert-Butyldimethlsilyl)Phenylephrine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.